期刊
DEVELOPMENTAL BIOLOGY
卷 330, 期 1, 页码 21-31出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2009.02.035
关键词
Notch; Wnt; Embryo; Mouse; Chick; Somite; Segmentation clock
资金
- Medical Research Council [G120/989] Funding Source: Medline
- NIDCR NIH HHS [R01 DE016082-04, R01 DE016082-01, R01 DE016082, R01 DE016082-05, R01 DE016082-03, R01 DE016082-02, R01 DE 016082-01, K08 DE016355, K08 DE 016355] Funding Source: Medline
- Wellcome Trust [089357] Funding Source: Medline
- Medical Research Council [G120/989] Funding Source: researchfish
- MRC [G120/989] Funding Source: UKRI
Somites are embryonic precursors of the ribs, vertebrae and certain dermis tissue. Somite formation is a periodic process regulated by a molecular clock which drives cyclic expression of a number of clock genes in the presomitic mesoderm. To date the mechanism regulating the period of clock gene oscillations is unknown. Here we show that chick homologues of the Wnt pathway genes that oscillate in mouse do not cycle across the chick presomitic mesoderm. Strikingly we find that modifying Wnt signalling changes the period of Notch driven oscillations in both mouse and chick but these oscillations continue. We propose that the Wnt pathway is a conserved mechanism that is involved in regulating the period of cyclic gene oscillations in the presomitic mesoderm. (C) 2009 Elsevier Inc. All rights reserved.
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