期刊
DEVELOPMENTAL BIOLOGY
卷 316, 期 1, 页码 110-123出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2008.01.016
关键词
planar cell polarity; Frizzled signaling; egf-receptor signaling; AP-1 transcription factor; retinal development
资金
- NEI NIH HHS [R01 EY013256, R01 EY013256-08, R01 EY13256] Funding Source: Medline
- NATIONAL EYE INSTITUTE [R01EY013256] Funding Source: NIH RePORTER
Frizzled (Fz)/PCP signaling regulates planar, vectorial orientation of cells or groups of cells within whole tissues. Although Fz/PCP signaling has been analyzed in several contexts, little is known about nuclear events acting downstream of Fz/PCP signaling in the R3/R4 cell fate decision in the Drosophila eye or in other contexts. Here we demonstrate a specific requirement for Egfir-signaling and the transcription factors Fos (AP-1), Yan and Put in PCP dependent R3/R4 specification. Loss and gain-of-function assays suggest that the transcription factors integrate input from Fz/ PCP and Egfr-signaling and that the ETS factors Pnt and Yan cooperate with Fos (and Jun) in the PCP-specific R3/R4 determination. Our data indicate that Fos (either downstream of Fz/PCP signaling or parallel to it) and Yan are required in R3 to specify its fate (Fos) or inhibit R4 fate (Yan) and that Egfr-signaling is required in R4 via Pnt for its fate specification. Taken together with previous work establishing a Notch-dependent Su(H) function in R4. we conclude that Fos, Yan, Put, and Su(H) integrate Egfr, Fz, and Notch signaling input in R3 or R4 to establish cell fate and ommatidial polarity. (C) 2008 Elsevier Inc. All rights reserved.
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