期刊
DEVELOPMENTAL BIOLOGY
卷 316, 期 1, 页码 87-99出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2008.01.006
关键词
Hey1; Hey2; Hesr3; Hey3; Notch; inner ear; hair cell; cochlea; prosensory
资金
- NICHD NIH HHS [T32 HD007183, P30HD002274, P30 HD002274] Funding Source: Medline
- NIDCD NIH HHS [P30DC004661, DC005953, R01 DC005953-02, R01 DC005953, P30 DC004661, R01 DC005953-03] Funding Source: Medline
- PHS HHS [T32 HDO7183] Funding Source: Medline
In cochlear development, the Notch signaling pathway is required for both the early prosensory phase and a later lateral inhibition phase. While it is known that Hes genes are important downstream mediators of Notch function in lateral inhibition, it is not known what genes function as mediators of the early prosensory function of Notch. We report that two members of the Hes-related gene family, Hesr1 and Hesr2, are expressed in the developing cochlea at a time and place that makes them excellent candidates as downstream mediators of Notch during prosensory specification. We also show that treatment of cochlear explant cultures at the time of prosensory specification with a small-molecule inhibitor of the Notch pathway mimics the results of conditional Jag1 deletion. This treatment also reduces Hesr1 and Hesr2 expression by as much as 80%. These results support the hypothesis that Hesr1 and Hesr2 are the downstream mediators of the prosensory function of Notch in early cochlear development. (C) 2008 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据