期刊
DEVELOPMENTAL BIOLOGY
卷 314, 期 1, 页码 127-136出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2007.11.018
关键词
MGE; somatostatin; parvalbumin; microarray; interneuron subtypes
资金
- NIMH NIH HHS [R01 MH066912, R01 MH066912-06, K02 MH070031-06, K02 MH070031] Funding Source: Medline
Although it is well established that the ventral telencephalon is the primary source of GABAergic cortical intemeurons in rodents, little is known about the specification of specific interneuron subtypes. It is also unclear whether the potential to achieve a given fate is established at their place of origin or by signals received during their migration to or during their maturation within the cerebral cortex. Using both in vivo and in vitro transplantation techniques, we find that two major interneuron subgroups have largely distinct origins within the MGE. Somatostatin (SST)expressing interneurons are primarily generated within the dorsal MGE, while parvalbumin (PV)-expressing interneurons primarily originate from the ventral MGE. In addition, we show that significant heterogeneity exists between gene expression patterns in the dorsal and ventral MGE. These results suggest that, like the spinal cord, neuronal fate determination in the ventral telencephalon is largely the result of spatially segregated, molecularly distinct microdomains arranged on the dorsal-ventral axis. (C) 2007 Elsevier Inc. All rights reserved.
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