期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 41, 期 3, 页码 413-417出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2013.04.008
关键词
Salmonella; Campylobacter; Toll-like receptors; Cytokines; Defensins; Macrophage; Lymphocyte
资金
- Biotechnology and Biological Sciences Research Council [BB/D007542/1] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/D007542/1] Funding Source: Medline
- BBSRC [BB/D007542/1] Funding Source: UKRI
Bacterial infections remain important to the poultry industry both in terms of animal and public health, the latter due to the importance of poultry as a source of foodborne bacterial zoonoses such as Salmonella and Campylobacter. As such, much focus of research to the immune response to bacterial infection has been to Salmonella. In this review we will focus on how research on avian salmonellosis has developed our understanding of immunity to bacteria in the chicken from understanding the role of TLRs in recognition of bacterial pathogens, through the role of heterophils, macrophages and gamma delta lymphocytes in innate immunity and activation of adaptive responses to the role of cellular and humoral immunity in immune clearance and protection. What is known of the immune response to other bacterial infections and in particular infections that have emerged recently as major problems in poultry production including Campylobacter jejuni, Avian Pathogenic Escherichia coli, Ornithobacterium rhinotracheale and Clostridium perfringens are discussed. (C) 2013 Elsevier Ltd. All rights reserved.
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