期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 36, 期 2, 页码 289-297出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2011.04.012
关键词
Conjunctiva-associated lymphoid tissue; Paraocular immunity; Avian immunity; Mucosal immunity
资金
- Animal Health and Disease Research grant
Conjunctiva-associated lymphoid tissue's (CALT) role in generating avian mucosal adaptive immunity was measured by analyzing cellular composition, expression of the polymeric immunoglobulin receptor (pIgR), and production of cytokines and antibodies in chickens ocular exposed to a replication-deficient adenovirus of serotype 5 (Ad5). These studies demonstrate that CALT contains B cells, 76 T cells, T helper, and cytotoxic T cells, and a T lymphocyte composition, which more resembles Harderian glands than spleen. CALT-derived lymphocytes contain antigen-specific, IgA-secreting plasma cells and cytokine-producing lymphocytes after ocular Ad5 vaccination. The expression of the pIgR in the CALT's lymphoepithelium emphasizes the importance of mucosal immune protection by paraocular lymphoid tissues. The CALT immune response after ocular Ad5 boosting was influenced by prior high dose in ovo Ad5 priming. Thus, both mucosal and systemic immunization influenced Ad5-induced IFN-gamma responses in CALT. (C) 2011 Elsevier Ltd. All rights reserved.
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