期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 37, 期 3-4, 页码 363-370出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2012.01.004
关键词
Pacific oyster; Bivalve mollusk; Innate immunity; Bactericidal/permeability-increasing protein; Proline-rich peptide; Defensin; Vibrio
资金
- Ifremer
- CNRS
- University of Montpellier 2
- Languedoc-Roussillon Region (chercheur(se) d'avenir REVAResp project)
- graduate scholarship from Program Becas Chile-CONICYT
Diverse families of antimicrobial peptides and proteins have been described in oysters. We investigated here how antimicrobials are involved in the immune response against a pathogenic strain of Vibrio splendidus. Oyster antimicrobials were shown to display a wide variety of expression profiles in hemocyte populations and tissues. Oyster defensins are constitutively expressed in specific tissues such as mantle (Cg-Defm) or hemocytes (Cg-Defhs), while Cg-BPI is inducible and Cg-Prp appears down-regulated in hemocytes upon infection. The migratory behavior of hemocytes that express the different antimicrobials was found to be involved in the oyster response to a pathogenic Vibrio infection. Indeed, it contributes to colocalize several antimicrobials that were shown here to have synergistic activities. We propose that such a synergy, which was evidenced both within and between families of antimicrobials, might compensate for the low concentration of antimicrobials in oyster tissues. (c) 2012 Elsevier Ltd. All rights reserved.
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