期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 38, 期 3, 页码 431-446出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2012.07.010
关键词
Rainbow trout; Atlantic salmon; Type I IL-1 beta; Type II IL-1 beta; Gene cloning; Expression
资金
- European Commission [007103]
- Public Authority of Applied Education and Training (KUWAIT)
- Scottish Government [FC1996]
- MASTS pooling initiative (The Marine Alliance for Science and Technology for Scotland)
To date two closely related interleukin-1 beta genes (IL-1 beta 1 and IL-beta 2) have been found in salmonids. The cloning of trout and salmon IL-1 beta 3, and a salmon IL-1 beta 4 pseudogene reveals that two types of IL-1 beta genes exist in teleost species. Type I teleost IL-1 beta genes, including salmonid IL-1 beta 3, share a similar 6 coding exon structure as in tetrapods. Type II teleost IL-1 beta genes, e.g. salmonid IL-1 beta 1-2, lack one or two coding exons at their 5'-end, and share higher identities within this subgroup than within the type I subgroup. Both types of IL-1 beta genes have been found in species of Salmoniformes, Perciformes and Beloniformes, suggesting the divergence occurred early in teleost evolution. Trout IL-1 beta 3 is highly expressed in ovary suggesting a role in reproduction. A relatively high constitutive expression in gills, spleen and kidney and the up-regulation by PAMPs, proinflammatory cytokines and viral infection suggests IL-1 beta 3 also has a role in inflammation and host defence. (C) 2012 Elsevier Ltd. All rights reserved.
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