期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 36, 期 2, 页码 349-358出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2011.06.001
关键词
Microtubule aggregate protein; Interferon-induced protein 44; Type I IFN; IFN-gamma Delayed-type hyper sensitivity; Th1-mediated immunity
资金
- Grants-in-Aid for Scientific Research [23658157] Funding Source: KAKEN
Delayed-type hypersensitivity (DTH) response mediated by antigen-specific Th1 cells is used as a test to detect exposure to tuberculosis in humans. Japanese flounder (Paralichthys olivaceus) microtubule aggregate protein homologue (PoMTAP) was identified as a gene strongly induced during fish DTH response. In this study, PoMTAP gene was cloned and its expression profile was analyzed. The PoMTAP gene has a transcriptional regulatory region that includes two interferon-stimulated response elements and two IFN-gamma activated sites. Expressions of PoMTAP and IFN-gamma genes were up-regulated at the same time points during the DTH response, Edwardsiella tarda infection and VHSV infection. Furthermore. PoMTAP gene expressing cells also expressed CD3 epsilon, confirming that PoMTAP is expressed by T lymphocytes. These results suggest that PoMTAP is a novel immune-related gene expressed by T lymphocytes that is preferentially induced by IFN-gamma and has a role in Th1-mediated immune responses in Japanese flounder. (C) 2011 Elsevier Ltd. All rights reserved.
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