期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 34, 期 6, 页码 625-629出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2010.01.006
关键词
Innate immunity; Toll pathway; Arbovirus; Dengue
资金
- National Institutes of Health/National Institute for Allergy and Infectious Disease [1R01AI061576-01A1, RO1AI059492, RO1AI078997]
- Johns Hopkins School of Public Health
- Johns Hopkins Malaria Research Institute
- NIH/NIAAD [1F31AI080161-01A1]
- American Society for Microbiology Robert D. Watkins Graduate Research Fellowship
Dengue virus has become one of the most important arboviral pathogens affecting the world today. The virus is transmitted among humans by the mosquitoes Aedes aegypti and Ae. albopictus. Like other vector-borne pathogens, this virus encounters innate immune defenses within the mosquito vector that limit infection. We have previously demonstrated the involvement of the Toll pathway in the anti-dengue defense at 7 days after infection. In the present study, we have investigated the activity of this immune signaling pathway against different dengue virus serotypes at the early stages of infection in laboratory and field-derived mosquito strains. Our studies corroborate the importance of the Toll pathway in the anti-dengue defense repertoire at 3 days after an infectious blood meal, when new virions are released from the midgut for dissemination and infection of other mosquito tissues. These immune defenses are furthermore conserved among different Ae. aegypti strains and can act against a broad range of dengue virus serotypes. (C) 2010 Elsevier Ltd. All rights reserved.
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