期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 34, 期 4, 页码 369-376出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2009.11.010
关键词
Gut immunity; Reactive oxygen species; Dual oxidase; Anti-microbial peptide; NF-kappa B; Drosophila
资金
- National Creative Research Initiative Program
- WCU [R31-2008-000-10010-0]
- Korea Ministry of Education, Science and Technology [21]
- National Research Foundation of Korea [R31-2008-000-10010-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Metazoan guts face a wide variety of microorganisms upon exposure to the environment, including beneficial symbionts, non-symbionts, food-borne microbes and life-threatening pathogens. Recent evidence has shown that the innate immunity of gut epithelia, such as anti-microbial peptide- and reactive oxygen species-based immune systems, actively participate in gut-microbe homeostasis by shaping the commensal community while efficiently eliminating unwanted bacteria. Therefore, elucidation of the regulatory mechanism by which gut innate immunity occurs at the molecular level will provide a novel perspective of gut-microbe mutualisms as well as of gut diseases caused by alterations in the innate immunity. (C) 2009 Elsevier Ltd. All rights reserved.
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