Synthesis of Perfluorinated Isoquinolinediones through Visible-Light-Induced Cyclization of Alkenes

A novel visible-light-induced carboperfluoroalkylation of alkenes using perfluoroalkyl iodides and bromides as R-f sources, leading to isoquinoline-1,3-diones, was developed. This method offers rapid entry to perfluorinated isoquinoline-1,3(2H,4H)-diones from N-alkyl-N-methacryloyl benzamides under mild reaction conditions, allowing for the incorporation of a wide variety of perfluorinated groups such as CF3, C3F7, C4F9, C6F13, C8F17, C10F21, and CF2CO2Et.