期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 33, 期 4, 页码 434-438出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2008.11.007
关键词
Antimicrobial peptide; Defensin; beta-Defensin; Six-cysteine motif; Innate immunity; Japanese spiny lobster; Panulirus japonicus; Phyllosoma
资金
- Ministry of Agriculture, Forestry, and Fisheries of Japan
- Ministry of Education, Culture, Sports, Science and Technology of Japan
Antimicrobial peptides (AMPs) are components of the innate immune responses that form the first line of host defense against pathogens. In this study, cDNAs of two new isoforms of defensin (designated PJD1 and PJD2) from a Japanese spiny lobster Panulirus japonicus haemocytes cDNA library were cloned and sequenced. PJD1 and PJD2 consist of 656 and 673 nucleotides encoding putative proteins of 66 and 64 amino acids, respectively. The isoforms share 74.2% amino acid identity. In a phylogenetic analysis, the peptides clustered with vertebrate defensins and were closely mostly related to chicken P-defensin. PJD1 and PJD2 were detected in all tissues examined including heart, nerves, intestine, haemocytes, gills and hepatopancreas. (C) 2008 Elsevier Ltd. All rights reserved.
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