期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 33, 期 11, 页码 1186-1195出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2009.06.010
关键词
Drosophila; Innate immunity; PEBP; Survival; 2D-DIGE; Hemolymph protein profile
资金
- Research Foundation Flanders (FWO-Vlaanderen) [G.0444.05, 1.5.137.06]
This study addresses the biological function of CG18594, a Drosophila melanogaster phosphatidylethanolamine-binding protein (PEBP) that we named PEBP1, by combining fly genetics, survival experiments and differential proteomics. We demonstrate that transgenic flies overexpressing PEBP1 are highly protected against bacterial infection due to the release of immunity-related proteins in their hemolymph. Apart from proteins that have been reported earlier to participate in insect immunity, we also identify proteins involved in metabolism and signaling, and, in addition, twelve (hypothetical) proteins with unknown function. This is the first report demonstrating an immune function for a Drosophila PEBP protein. (C) 2009 Elsevier Ltd. All rights reserved.
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