期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 33, 期 10, 页码 1064-1069出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2009.05.008
关键词
Bombyx mori; Transferrin; Antimicrobial activity; Innate immunity
资金
- Korean Government (MOEHRD) [KRF-2007-611-C00001]
- Agenda program, Rural Development Administration, Korea [200902FHT010102002]
- BioGreen 21 Program [20070401034024]
- Rural Development Administration, Korea
- National Research Foundation of Korea [전06A1115, 2006-0050687] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Rural Development Administration (RDA), Republic of Korea [20070401034024] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Transferrin (Tf) is a multifunctional, iron binding protein found in both vertebrates and invertebrates. Although transferrin has been suggested to play a role in innate immunity, its immunological function during infection has not been characterized. In this study, we identified and characterized Bombyx mori transferrin (BmTf). The promoter region of BmTf has numerous putative NF-kappa B binding sites, suggesting its possible function in innate immunity. Analysis of BmTf gene expression shows that it is highly inducible in response to a wide variety of pathogens including bacteria, fungus, and viruses. Recombinant BmTf protein produced in a baculovirus system exhibits iron binding capacity and antibacterial activity against various Gram-positive and -negative bacteria. Taken together, our results indicate that BmTf is an inducible immune effector molecule that may play an important role in pathogen clearance of insect innate immunity. (C) 2009 Elsevier Ltd. All rights reserved.
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