期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 80, 期 14, 页码 6959-6967出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b00407
关键词
-
资金
- Development and Promotion of Science and Technology Talents Project (DPST) (Royal Government of Thailand scholarship) of Thailand
- Japan Society for the Promotion of Science (JSPS)
- Kyoto University [24245005, 26105733, 15H02158]
- Grants-in-Aid for Scientific Research [26104519, 26810005, 26105733, 15KT0142] Funding Source: KAKEN
The recently developed artificial force induced reaction (AFIR) method was applied to search systematically all possible multicomponent pathways for the Biginelli reaction mechanism. The most favorable pathway starts with the condensation of the urea and benzaldehyde, followed by the addition of ethyl acetoacetate. Remarkably, a second urea molecule catalyzes nearly every step of the reaction. Thus, the Biginelli reaction is a urea-catalyzed multicomponent reaction. The reaction mechanism was found to be identical in both protic and aprotic solvents.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据