期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 32, 期 12, 页码 1561-1571出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2008.05.014
关键词
haemocyte; haemolymph; mollusc innate immunity; mitogen-activated protein kinase (MAPK); extracellular signal-regulated kinase (ERK); immune evasion; host-parasite interaction; excretory-secretory products
资金
- Higher Education for England (HEFCE) Promising Researcher Fellowship
Biomphalaria glabrata is an intermediate snail host for the human blood fluke Schistosoma mansoni. To survive in B. glabrata, S. mansoni must suppress the snail's haemocyte-mediated defence response; the molecular mechanisms by which this is achieved remain largely unknown. We report here that S. monsoni excretory-secretory products (ESPs) attenuate phosphorylation of extracellular signal-regulated kinase (ERK) in haemocytes from a B. glabrato strain susceptible to S. mansoni. Whole S. monsoni sporocysts also impair ERK signalling in these cells. In striking contrast, ERK signalling in haemocytes from a B. glabrata strain refractory to schistosome infection is unaffected by ESPs or sporocysts. Effects of ESPs on ERK are similar in the presence or absence of snail plasma, thus ESPs seem to affect haemocytes directly. These findings reveal novel schistosome interference mechanisms; as ERK regulates various haemocyte defence reactions, we propose that disruption of ERK signalling in haemocytes facilitates S. mansoni survival within susceptible B. glabrata. (C) 2008 Elsevier Ltd. All rights reserved.
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