期刊
DEVELOPMENT GROWTH & DIFFERENTIATION
卷 53, 期 7, 页码 843-856出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1440-169X.2011.01292.x
关键词
beta-catenin dependent pathway; lineage differentiation; pluripotency; stem cells; WNT signaling
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT)
- Japan Society for Promotion of Science (JSPS)
- (Cell Fate Regulation Research and Education Unit) of MEXT
- Australian Research Council
- National Health & Medical Research Council of Australia (NHMRC)
- Suzuki Manpei Diabetes Foundation
- Grants-in-Aid for Scientific Research [21116003, 23570258, 23013018, 22770220] Funding Source: KAKEN
WNT signaling activity is involved in the regulation of many cellular functions, including proliferation, migration, cell fate specification, maintenance of pluripotency and induction of tumorigenicity. Here we summarize recent progress towards understanding the regulation of canonical WNT/beta-catenin signaling activity through feedback regulatory loops involving the ligands, agonists and antagonists, the availability of intracellular pools of active beta-catenin and the cross-regulation of the WNT activity by beta-catenin independent pathway. We also review recent findings on the role of WNT/beta-catenin signaling in tissue lineage differentiation during embryogenesis and the maintenance and self renewal of embryo-derived stem cells in vitro.
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