期刊
DEVELOPMENT GROWTH & DIFFERENTIATION
卷 52, 期 3, 页码 275-283出版社
WILEY
DOI: 10.1111/j.1440-169X.2009.01166.x
关键词
embryonic stem cells; epiblasts; primitive ectoderm; primitive endoderm; trophectoderm
Mouse embryonic stem (mES) cells are pluripotent stem cells derived from pre-implantation embryos. They are regarded as an essential tool for studying mouse development, as they provide a means for generating knock-out mouse lines. This, however, is not the sole utility of the mES cell system. They undergo differentiation in culture, mimicking the morphological differentiation of peri-implantation embryos from epiblast to egg-cylinder stage. Moreover, they retain the capacity to respond to triggers of differentiation toward trophectoderm and primitive endoderm by forced activation. For these reasons, mES cells can be regarded as a useful tool for analyzing molecular mechanisms underlying early mouse development.
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