期刊
DEVELOPMENT GROWTH & DIFFERENTIATION
卷 51, 期 3, 页码 233-240出版社
WILEY
DOI: 10.1111/j.1440-169X.2009.01092.x
关键词
axonal pathfinding; neural migration; non-canonical Wnt signaling; planar cell polarity; zebrafish
资金
- Ministry of Education, Science, Technology, Sports and Culture of Japan
- Core Research for Evolutional Science and Technology from Japan Science and Technology Corporation (JST)
Planar cell polarity (PCP) in epithelial cells is essential for the organization of tissues and their functions. The conserved non-canonical Wnt/PCP pathway regulates this process in both Drosophila and vertebrates. However, recent studies have revealed that a similar set of genes, which may not be related to PCP, regulates oriented cell movement during development. In the present review, recent findings on neural migration in zebrafish hindbrain and axonal guidance in mouse forebrain and spinal cord are discussed. Future analyses on defects in vertebrate PCP mutants will provide novel insights into the conserved and diverse roles of non-canonical Wnt/PCP pathway genes in vertebrate brain development.
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