期刊
DEVELOPMENT
卷 141, 期 13, 页码 2543-2548出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.108712
关键词
Amyloid precursor protein; Neural development; Axonal outgrowth; Synapse formation
资金
- Vlaams Institut voor Biotechnologie (VIB)
- Fonds Wetenschaplijk Onderzoeks (FWO)
- Belgian Science Policy (BELSPO)
- KU Leuven
- European Commission
Interest in the amyloid precursor protein (APP) has increased in recent years due to its involvement in Alzheimer's disease. Since its molecular cloning, significant genetic and biochemical work has focused on the role of APP in the pathogenesis of this disease. Thus far, however, these studies have failed to deliver successful therapies. This suggests that understanding the basic biology of APP and its physiological role during development might be a crucial missing link for a better comprehension of Alzheimer's disease. Here, we present an overview of some of the key studies performed in various model organisms that have revealed roles for APP at different stages of neuronal development.
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