期刊
DEVELOPMENT
卷 141, 期 20, 页码 3834-3841出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.102368
关键词
Cell cycle; Embryonic development; Gap phases
资金
- UK Medical Research Council Programme [A252-5RG50]
- Wellcome Trust Sanger Institute
- Wellcome Trust
- Medical Research Council [MC_U117597140] Funding Source: researchfish
- MRC [MC_U117597140] Funding Source: UKRI
The initial phases of embryonic development occur in the absence of de novo transcription and are instead controlled by maternally inherited mRNAs and proteins. During this initial period, cell cycles are synchronous and lack gap phases. Following this period of transcriptional silence, zygotic transcription begins, the maternal influence on development starts to decrease, and dramatic changes to the cell cycle take place. Here, we discuss recent work that is shedding light on the maternal to zygotic transition and the interrelated but distinct mechanisms regulating the onset of zygotic transcription and changes to the cell cycle during early embryonic development.
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