期刊
DEVELOPMENT
卷 141, 期 9, 页码 1789-1793出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.091645
关键词
Adhesion; Contractility; Mechanics; Morphogenesis; Myosin
资金
- Centre National de la Recherche Scientifique (CNRS)
- European Research Council (ERC)
- Association pour la Recherche Contre le Cancer (ARC)
- Agence Nationale de la Recherche
Tissue morphogenesis is driven by coordinated cellular deformations. Recent studies have shown that these changes in cell shape are powered by intracellular contractile networks comprising actin filaments, actin cross-linkers and myosin motors. The subcellular forces generated by such actomyosin networks are precisely regulated and are transmitted to the cell cortex of adjacent cells and to the extracellular environment by adhesive clusters comprising cadherins or integrins. Here, and in the accompanying poster, we provide an overview of the mechanics, principles and regulation of actomyosin-driven cellular tension driving tissue morphogenesis.
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