期刊
DEVELOPMENT
卷 141, 期 6, 页码 1381-1391出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.093435
关键词
Fgf signaling; Wnt signaling; Embryonic elongation; Segmentation clock; Signal gradient; Time-lapse microscopy
资金
- Max Planck Society
- Human Frontier Science Program (HFSP)
- Marie Curie
- European Research Council (ERC) under the European Communities 7th Framework Programme [FP7]/[ERC] [207634]
- German Research Foundation Normalverfaren [OA 53/2-1]
- Spanish Ministry of Economy and Competitiveness (MINECO) grant PHYSDEV [FIS2012-32349]
- Wellcome Trust [WT098025MA]
- Medical Research Council (MRC) [MC_UP_1202/3]
- MRC [MC_UP_1202/3] Funding Source: UKRI
- Medical Research Council [MC_UP_1202/3] Funding Source: researchfish
How signaling gradients supply positional information in a field of moving cells is an unsolved question in patterning and morphogenesis. Here, we ask how a Wnt signaling gradient regulates the dynamics of a wavefront of cellular change in a flow of cells during somitogenesis. Using time-controlled perturbations of Wnt signaling in the zebrafish embryo, we changed segment length without altering the rate of somite formation or embryonic elongation. This result implies specific Wnt regulation of the wavefront velocity. The observed Wnt signaling gradient dynamics and timing of downstream events support a model for wavefront regulation in which cell flow plays a dominant role in transporting positional information.
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