期刊
DEVELOPMENT
卷 141, 期 6, 页码 1179-1183出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.088492
关键词
Pol II pausing; Transcription elongation; Developmental control genes
资金
- Stowers Institute for Medical Research
- National Institutes of Health
The rapid expansion of genomics methods has enabled developmental biologists to address fundamental questions of developmental gene regulation on a genome-wide scale. These efforts have demonstrated that transcription of developmental control genes by RNA polymerase II (Pol II) is commonly regulated at the transition to productive elongation, resulting in the promoter-proximal accumulation of transcriptionally engaged but paused Pol II prior to gene induction. Here we review the mechanisms and possible functions of Pol II pausing and their implications for development.
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