期刊
DEVELOPMENT
卷 142, 期 2, 页码 314-319出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.115998
关键词
Vascular endothelial growth factor (VEGF); VEGF189; Neuron; Neuropilin; Mouse
资金
- Wellcome Trust PhD fellowship [092839/Z/10/Z]
- BBSRC project grant [BB/J00930X/1]
- Wellcome Trust [092839/Z/10/Z] Funding Source: Wellcome Trust
- Biotechnology and Biological Sciences Research Council [BB/J00815X/1, BB/J00930X/1] Funding Source: researchfish
- BBSRC [BB/J00930X/1, BB/J00815X/1] Funding Source: UKRI
The vascular endothelial growth factor (VEGFA, VEGF) regulates neurovascular patterning. Alternative splicing of the Vegfa gene gives rise to three major isoforms termed VEGF(121), VEGF(165) and VEGF(189). VEGF(165) binds the transmembrane protein neuropilin 1 (NRP1) and promotes the migration, survival and axon guidance of subsets of neurons, whereas VEGF(121) cannot activate NRP1-dependent neuronal responses. By contrast, the role of VEGF(189) in NRP1-mediated signalling pathways has not yet been examined. Here, we have combined expression studies and in situ ligand-binding assays with the analysis of genetically altered mice and in vitro models to demonstrate that VEGF(189) can bind NRP1 and promote NRP1-dependent neuronal responses.
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