期刊
DEVELOPMENT
卷 141, 期 11, 页码 2245-2254出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.103960
关键词
EKLF/KLF1; Erythroblastic island; Erythroid-myeloid progenitor; Mouse
资金
- National Institutes of Health (NIH) [K08 DK002871, R01 DK77822]
- Black Family Stem Cell Institute Exploratory Research Grant
The erythroblastic island provides an important nutritional and survival support niche for efficient erythropoietic differentiation. Island integrity is reliant on adhesive interactions between erythroid and macrophage cells. We show that erythroblastic islands can be formed from single progenitor cells present in differentiating embryoid bodies, and that these correspond to erythro-myeloid progenitors (EMPs) that first appear in the yolk sac of the early developing embryo. Erythroid Kruppel-like factor (EKLF; KLF1), a crucial zinc finger transcription factor, is expressed in the EMPs, and plays an extrinsic role in erythroid maturation by being expressed in the supportive macrophage of the erythroblastic island and regulating relevant genes important for island integrity within these cells. Together with its well-established intrinsic contributions to erythropoiesis, EKLF thus plays a coordinating role between two different cell types whose interaction provides the optimal environment to generate a mature red blood cell.
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