期刊
DEVELOPMENT
卷 140, 期 22, 页码 4471-4479出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.090613
关键词
Fertilization; Izumo1; Acrosome reaction; Eggs; Hyperactivation; Spermatozoa
Fertilization is the process by which eggs and spermatozoa interact, achieve mutual recognition, and fuse to create a zygote, which then develops to form a new individual, thus allowing for the continuity of a species. Despite numerous studies on mammalian fertilization, the molecular mechanisms underpinning the fertilization event remain largely unknown. However, as I summarize here, recent work using both gene-manipulated animals and in vitro studies has begun to elucidate essential sperm and egg molecules and to establish predictive models of successful fertilization.
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