期刊
DEVELOPMENT
卷 140, 期 4, 页码 689-704出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.080614
关键词
Notch; Differentiation; Fate decisions; Self-renewing tissues; Stem cells
资金
- Swiss National Science Foundation
- Swiss Cancer League
- Marie Curie Foundation
- EuroSyStem
- OptiStem
Notch signaling has been shown over the past few decades to play fundamental roles in a plethora of developmental processes in an evolutionarily conserved fashion. Notch-mediated cell-to-cell signaling is involved in many aspects of embryonic development and control of tissue homeostasis in a variety of adult tissues, and regulates stem cell maintenance, cell differentiation and cellular homeostasis. The focus of this Review is the role of Notch signaling in stem cells, comparing insights from flies, fish and mice to highlight similarities, as well as differences, between species, tissues and stem cell compartments.
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