期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 80, 期 3, 页码 1789-1794出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo502709t
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资金
- Young Scientific Talent Seed Foundation of Henan University [0000A40477]
- Ph.D. Scientific Research Starting Foundation of Henan University [B2012048]
- National Natural Science Foundation of China [51403051]
A simple and efficient copper-catalyzed one-pot synthesis of substituted 1,2,4-triazoles through reactions of two nitriles with hydroxylamine has been developed. The protocol uses simple and readily available nitriles and hydroxylamine hydrochloride as the starting materials and inexpensive Cu(OAc)(2) as the catalyst, and the corresponding 1,2,4-triazole derivatives are obtained in moderate to good yields. The reactions include sequential intermolecular addition of hydroxylamine to one nitrile to provide amidoxime, copper-catalyzed treatment of the amidoxime with another nitrile, and intramolecular dehydration/cyclization. This finding provides a new and useful strategy for synthesis of 1,2,4-triazole derivatives.
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