期刊
DEVELOPMENT
卷 139, 期 22, 页码 4105-4109出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.074997
关键词
Cell migration; Eph; Ephrin-mediated vascular development; Axon guidance; Topographic mapping
资金
- Max-Planck Society
- Deutsche Forschungsgemeinschaft [SFB870]
- European Union
Eph receptors and their membrane-tethered ligands have important functions in development. Trans interactions of Eph receptors with ephrins at cell-cell interfaces promote a variety of cellular responses, including repulsion, attraction and migration. Eph-ephrin signalling can be bi-directional and controls actin cytoskeleton dynamics, thereby leading to changes in cellular shape. This article provides an overview of the general structures and signalling mechanisms, and of typical developmental functions along with cell biological principles.
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