期刊
DEVELOPMENT
卷 139, 期 22, 页码 4180-4190出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.085407
关键词
APETALA2; Floral development; Transcriptional repression; Arabidopsis
资金
- National Institutes of Health [GM072764]
- National Science Foundation [IOS0822411]
- Natural Sciences and Engineering Research Council
- San Diego Foundation
The development and coordination of complex tissues in eukaryotes requires precise spatial control of fate-specifying genes. Although investigations of such control have traditionally focused on mechanisms of transcriptional activation, transcriptional repression has emerged as being equally important in the establishment of gene expression territories. In the angiosperm flower, specification of lateral organ fate relies on the spatial regulation of the ABC floral organ identity genes. Our understanding of how the boundaries of these expression domains are controlled is not complete. Here, we report that the A-class organ identity gene APETALA2 (AP2), which is known to repress the C-class gene AGAMOUS, also regulates the expression borders of the B-class genes APETALA3 and PISTILLATA, and the E-class gene SEPALLATA3. We show that AP2 represses its target genes by physically recruiting the co-repressor TOPLESS and the histone deacetylase HDA19. These results demonstrate that AP2 plays a broad role in flower development by controlling the expression domains of numerous floral organ identity genes.
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