4.7 Article

Draper acts through the JNK pathway to control synchronous engulfment of dying germline cells by follicular epithelial cells

期刊

DEVELOPMENT
卷 139, 期 21, 页码 4029-4039

出版社

COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.082776

关键词

Engulfment; Drosophila; Ovary; Cell death

资金

  1. National Institutes of Health (NIH) [R01 GM060574, R01 GM094452, F31 GM099425]
  2. National Science Foundation-Research Experience for Undergraduates (NSF-REU)
  3. NSF ProStars
  4. Boston University Undergraduate Research Opportunities Program (UROP)
  5. Direct For Biological Sciences
  6. Div Of Biological Infrastructure [0851711] Funding Source: National Science Foundation

向作者/读者索取更多资源

The efficient removal of dead cells is an important process in animal development and homeostasis. Cell corpses are often engulfed by professional phagocytes such as macrophages. However, in some tissues with limited accessibility to circulating cells, engulfment is carried out by neighboring non-professional phagocytes such as epithelial cells. Here, we investigate the mechanism of corpse clearance in the Drosophila melanogaster ovary, a tissue that is closed to circulating cells. In degenerating egg chambers, dying germline cells are engulfed by the surrounding somatic follicular epithelium by unknown mechanisms. We show that the JNK pathway is activated and required in engulfing follicle cells. We find that the receptor Draper is also required in engulfing follicle cells, and activates the JNK pathway. Overexpression of Draper or the JNK pathway in follicle cells is sufficient to induce death of the underlying germline, suggesting that there is coordination between the germline and follicular epithelium to promote germline cell death. Furthermore, activation of JNK bypasses the need for Draper in engulfment. The induction of JNK and Draper in follicle cells occurs independently of caspase activity in the germline, indicating that at least two pathways are necessary to coordinate germline cell death with engulfment by the somatic epithelium.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据