期刊
DEVELOPMENT
卷 139, 期 22, 页码 4111-4121出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.079590
关键词
Crypt; Pituitary development; Retinal development; Self-organisation; Stem cells; Three-dimensional culture
资金
- Leading Project for Realization of Regenerative Medicine
- Ministry of Education, Culture, Sports, Science and Technology
- Grants-in-Aid for Scientific Research [24680037] Funding Source: KAKEN
Organ formation during embryogenesis is a complex process that involves various local cell-cell interactions at the molecular and mechanical levels. Despite this complexity, organogenesis can be modelled in vitro. In this article, we focus on two recent examples in which embryonic stem cells can self-organise into three-dimensional structures - the optic cup and the pituitary epithelium; and one case of self-organising adult stem cells - the gut epithelium. We summarise how these approaches have revealed intrinsic programs that drive locally autonomous modes of organogenesis and homeostasis. We also attempt to interpret the results of previous in vivo studies of retinal development in light of the self-organising nature of the retina.
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