期刊
DEVELOPMENT
卷 139, 期 8, 页码 1371-1380出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.072348
关键词
VEGF-A; Vegfa; Axon guidance; Neurogenesis; Neuron; Neuronal migration and survival
资金
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council (BBSRC)
- British Heart Foundation (BHF)
- Biotechnology and Biological Sciences Research Council [BB/I008373/1] Funding Source: researchfish
- British Heart Foundation [PG/10/86/28622] Funding Source: researchfish
- BBSRC [BB/I008373/1] Funding Source: UKRI
Vascular endothelial growth factor A (VEGF-A) is best known for its essential roles in blood vessel growth. However, evidence has emerged that VEGF-A also promotes a wide range of neuronal functions, both in vitro and in vivo, including neurogenesis, neuronal migration, neuronal survival and axon guidance. Recent studies have employed mouse models to distinguish the direct effects of VEGF on neurons from its indirect, vessel-mediated effects. Ultimately, refining our knowledge of VEGF signalling pathways in neurons should help us to understand how the current use of therapeutics targeting the VEGF pathway in cancer and eye disease might be expanded to promote neuronal health and nerve repair.
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