期刊
DEVELOPMENT
卷 139, 期 6, 页码 1071-1082出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.069070
关键词
Hes; Notch signaling; Intestinal tumor; Intestine; Stem cell; Mouse
资金
- Japan Society for the Promotion of Science (JSPS) [21229009, 23590937, 22790642]
- Ministry of Health, Labor and Welfare, Japan
- Grants-in-Aid for Scientific Research [24659363, 22790642, 24590916, 21229009, 21240028, 22687017, 23590937] Funding Source: KAKEN
Notch signaling regulates intestinal development, homeostasis and tumorigenesis, but its precise downstream mechanism remains largely unknown. Here we found that inactivation of the Notch effectors Hes1, Hes3 and Hes5, but not Hes1 alone, led to reduced cell proliferation, increased secretory cell formation and altered intestinal structures in adult mice. However, in Apc mutation-induced intestinal tumors, inactivation of Hes1 alone was sufficient for reducing tumor cell proliferation and inducing differentiation of tumor cells into all types of intestinal epithelial cells, but without affecting the homeostasis of normal crypts owing to genetic redundancy. These results indicated that Hes genes cooperatively regulate intestinal development and homeostasis and raised the possibility that Hes1 is a promising target to induce the differentiation of tumor cells.
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