期刊
DEVELOPMENT
卷 139, 期 19, 页码 3487-3497出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.085084
关键词
Evo-devo; Patterning; Teeth; Tooth shape; Tooth replacement
资金
- Academy of Finland
- Sigrid Juselius Foundation
Teeth are found in almost all vertebrates, and they therefore provide a general paradigm for the study of epithelial organ development and evolution. Here, we review the developmental mechanisms underlying changes in tooth complexity and tooth renewal during evolution, focusing on recent studies of fish, reptiles and mammals. Mammals differ from other living vertebrates in that they have the most complex teeth with restricted capacity for tooth renewal. As we discuss, however, limited tooth replacement in mammals has been compensated for in some taxa by the evolution of continuously growing teeth, the development of which appears to reuse the regulatory pathways of tooth replacement.
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