期刊
DEVELOPMENT
卷 139, 期 22, 页码 4232-4238出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.081901
关键词
Embryonic polarity; GATA factors; Chick embryo; Gastrulation; Primitive streak formation; Nodal; Vg1; Gdf-1; Embryonic regulation; Regeneration
资金
- Biotechnology and Biological Sciences Research Council (BBSRC)
- European Research Council (ERC)
- Spanish Ministry of Science and Innovation
- MRC [G0700095] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/C512753/1] Funding Source: researchfish
- Medical Research Council [G0700095] Funding Source: researchfish
The first axis to be specified during vertebrate development is that between the site where gastrulation will begin and the opposite pole of the embryo (dorsoventral axis in amphibians and fish, anteroposterior in amniotes). This relies on Nodal activity, but different vertebrates differ in how this activity is positioned. In chick, the earliest known asymmetry is posterior expression of the TGF beta-related factor Vg1, close to the future Nodal expression domain. Here we show that the transcription factor Gata2 is expressed anteriorly before this stage. Gata2 influences the site of primitive streak formation and its role is independent from, and upstream of, Vg1 and Wnt. However, although Vg1 is required for streak formation, Gata2 does not act as an absolute anterior specifier, but provides an anterior bias. These findings point to previously unsuspected global determinants of polarity of the early amniote embryo.
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