期刊
DEVELOPMENT
卷 139, 期 21, 页码 3905-3916出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.080440
关键词
Transcription factors; Gene regulation; Lineage commitment
资金
- National Institutes of Health Chicago Center for Systems Biology
- National Cancer Institute
- Samuel Waxman Foundation for Cancer Research
- National Science Foundation Graduate Research Fellowship Program
- Chicago Center for Systems Biology
- Robert H. Lurie Comprehensive Cancer Center Malkin Award
The development of complex organisms requires the formation of diverse cell types from common stem and progenitor cells. GATA family transcriptional regulators and their dedicated cofactors, termed Friend of GATA (FOG) proteins, control cell fate and differentiation in multiple tissue types from Drosophila to man. FOGs can both facilitate and antagonize GATA factor transcriptional regulation depending on the factor, cell, and even the specific gene target. In this review, we highlight recent studies that have elucidated mechanisms by which FOGs regulate GATA factor function and discuss how these factors use these diverse modes of gene regulation to control cell lineage specification throughout metazoans.
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