期刊
DEVELOPMENT
卷 138, 期 3, 页码 565-575出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.056903
关键词
Gastrulation; PDGF-A; Intercalation; Xenopus; Cell migration
资金
- Canadian Institutes of Health Research [MOP-53075]
Radial intercalation is a common, yet poorly understood, morphogenetic process in the developing embryo. By analyzing cell rearrangement in the prechordal mesoderm during Xenopus gastrulation, we have identified a mechanism for radial intercalation. It involves cell orientation in response to a long-range signal mediated by platelet-derived growth factor (PDGF-A) and directional intercellular migration. When PDGF-A signaling is inhibited, prechordal mesoderm cells fail to orient towards the ectoderm, the endogenous source of PDGF-A, and no longer migrate towards it. Consequently, the prechordal mesoderm fails to spread during gastrulation. Orientation and directional migration can be rescued specifically by the expression of a short splicing isoform of PDGF-A, but not by a long matrix-binding isoform, consistent with a requirement for long-range signaling.
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