期刊
DEVELOPMENT
卷 138, 期 17, 页码 3593-3612出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.063610
关键词
Cis-inhibition; Delta-like; Signaling diversity; Jagged; Notch; Notch intracellular domain
资金
- EU
- Swedish Cancer Society
- Swedish Research Council
- Strategic Research Center in Stem Cells and Regenerative Medicine (StratRegen)
- Knut och ALice Wallenbergs Stiftelse (WIRM)
- VINNOVA (AZ-KI Gene)
- Karolinska Institutet
- European Research Council
Notch signaling is evolutionarily conserved and operates in many cell types and at various stages during development. Notch signaling must therefore be able to generate appropriate signaling outputs in a variety of cellular contexts. This need for versatility in Notch signaling is in apparent contrast to the simple molecular design of the core pathway. Here, we review recent studies in nematodes, Drosophila and vertebrate systems that begin to shed light on how versatility in Notch signaling output is generated, how signal strength is modulated, and how cross-talk between the Notch pathway and other intracellular signaling systems, such as the Wnt, hypoxia and BMP pathways, contributes to signaling diversity.
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