期刊
DEVELOPMENT
卷 138, 期 11, 页码 2153-2169出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.044529
关键词
DCC; Adhesion; Axon; Neogenin; Netrin; UNC5
资金
- Canadian Institutes of Health Research (CIHR)
- Jeanne-Timmins Costello Graduate Fellowship
- Fonds de la Recherche en Sante du Quebec
Netrins are secreted proteins that were first identified as guidance cues, directing cell and axon migration during neural development. Subsequent findings have demonstrated that netrins can influence the formation of multiple tissues, including the vasculature, lung, pancreas, muscle and mammary gland, by mediating cell migration, cell-cell interactions and cell-extracellular matrix adhesion. Recent evidence also implicates the ongoing expression of netrins and netrin receptors in the maintenance of cell-cell organisation in mature tissues. Here, we review the mechanisms involved in netrin signalling in vertebrate and invertebrate systems and discuss the functions of netrin signalling during the development of neural and non-neural tissues.
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