期刊
DEVELOPMENT
卷 139, 期 1, 页码 15-31出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.050849
关键词
DNA demethylation; Epigenetic reprogramming; Pre-implantation embryos; Primordial germ cells; TET proteins
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- JST-CREST/ERATO
- Takeda Science Foundation
- Uehara Memorial Foundation
- Mitsubishi Foundation
Epigenetic modifications are crucial for the identity and stability of cells, and, when aberrant, can lead to disease. During mouse development, the genome-wide epigenetic states of pre-implantation embryos and primordial germ cells (PGCs) undergo extensive reprogramming. An improved understanding of the epigenetic reprogramming mechanisms that occur in these cells should provide important new information about the regulation of the epigenetic state of a cell and the mechanisms of induced pluripotency. Here, we discuss recent findings about the potential mechanisms of epigenetic reprogramming, particularly genome-wide DNA demethylation, in pre-implantation mouse embryos and PGCs.
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