期刊
DEVELOPMENT
卷 138, 期 22, 页码 4867-4874出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.071571
关键词
Dorsal gradient; Drosophila embryo; Computational biology; Confidence interval; Morphogen gradient; Statistics
资金
- National Science Foundation [DBI-0649833, 1136913]
- National Institutes of Health [NS058465]
- Sloan Foundation
- DuPont Young Professor grant
A crucial issue in studies of morphogen gradients relates to their range: the distance over which they can act as direct regulators of cell signaling, gene expression and cell differentiation. To address this, we present a straightforward statistical framework that can be used in multiple developmental systems. We illustrate the developed approach by providing a point estimate and confidence interval for the spatial range of the graded distribution of nuclear Dorsal, a transcription factor that controls the dorsoventral pattern of the Drosophila embryo.
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