期刊
DEVELOPMENT
卷 138, 期 5, 页码 831-837出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.057901
关键词
Stem cells; Asymmetric division; Spindle repositioning; Drosophila
资金
- University of Michigan
- March of Dimes Basil O'Conner Starter Scholar Research Award
- Searle Scholar Program [NIH R01GM086481, NIH R01GM072006]
Many stem cells divide asymmetrically to balance self-renewal and differentiation. In Drosophila testes, two stem cell populations, germline stem cells (GSCs) and somatic cyst stem cells (CySCs), cohere and regulate one another. Here, we report that CySCs divide asymmetrically through repositioning the mitotic spindle around anaphase. CySC spindle repositioning requires functional centrosomes, Dynein and the actin-membrane linker Moesin. Anaphase spindle repositioning is required to achieve high-fidelity asymmetric divisions in CySCs, thus maintaining both GSC and CySC numbers. We propose that dynamic spindle repositioning allows CySCs to divide asymmetrically while accommodating the structure of the GSCs they encapsulate.
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