期刊
DEVELOPMENT
卷 138, 期 15, 页码 3189-3198出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.063073
关键词
APETALA1; LEAFY; LMI2; Meristem identity transition; Reproductive development; Arabidopsis
资金
- NSF [IOS 0849298]
- NIH [5-T32-HD007516]
- University of Pennsylvania, School of Arts and Sciences
The switch from producing vegetative structures (branches and leaves) to producing reproductive structures (flowers) is a crucial developmental transition that significantly affects the reproductive success of flowering plants. In Arabidopsis, this transition is in large part controlled by the meristem identity regulator LEAFY (LFY). The molecular mechanisms by which LFY orchestrates a precise and robust switch to flower formation is not well understood. Here, we show that the direct LFY target LATE MERISTEM IDENTITY2 (LMI2) has a role in the meristem identity transition. Like LFY, LMI2 activates AP1 directly; moreover, LMI2 and LFY interact physically. LFY, LMI2 and AP1 are connected in a feed-forward and positive feedback loop network. We propose that these intricate regulatory interactions not only direct the precision of this crucial developmental transition in rapidly changing environmental conditions, but also contribute to its robustness and irreversibility.
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