期刊
DEVELOPMENT
卷 137, 期 23, 页码 3921-3930出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.048983
关键词
Sry; Sex determination; Sox9; Testis; Sertoli cell
资金
- Australian Research Council (ARC)
- National Health and Medical Research Council (NHMRC) of Australia
SRY, the mammalian Y-chromosomal testis-determining gene, induces male sex determination. Recent studies in mice reveal that the major role of SRY is to achieve sufficient expression of the related gene Sox9, in order to induce Sertoli cell differentiation, which in turn drives testis formation. Here, we discuss the cascade of events triggered by SRY and the mechanisms that reinforce the differentiation of the testes in males while actively inhibiting ovarian development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据