期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 80, 期 10, 页码 5308-5314出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b00452
关键词
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资金
- EPSRC
- Pfizer Neusentis
- Astra Zeneca
- Engineering and Physical Sciences Research Council [1354666, EP/F068158/1, 1355114] Funding Source: researchfish
- EPSRC [EP/F068158/1] Funding Source: UKRI
In the absence of a steric directing group, iridium-catalyzed. C-H borylation of N-protected indazoles occurs rapidly and selectively at C-3 and the resulting boronate esters can be utilized in a range of downstream conversions. The functional group tolerance of the iridium-catalyzed C-H borylation reaction enables simple and efficient multidirectional syntheses of substituted indazoles to be realized.
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