期刊
DEVELOPMENT
卷 137, 期 9, 页码 1451-1460出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.048496
关键词
FoxF; FoxC; let-381; Forkhead domain; ceh-34; SIX2 homeodomain; eya-1; Eyes absent; Mesoderm; Cell fate specification; M lineage; Coelomocyte; Asymmetry; C. elegans
资金
- NIH [R01 GM066953]
Forkhead transcription factors play crucial and diverse roles in mesoderm development. In particular, FoxF and FoxC genes are, respectively, involved in the development of visceral/splanchnic mesoderm and non-visceral mesoderm in coelomate animals. Here, we show at single-cell resolution that, in the pseudocoelomate nematode C. elegans, the single FoxF/FoxC transcription factor LET-381 functions in a feed-forward mechanism in the specification and differentiation of the non-muscle mesodermal cells, the coelomocytes (CCs). LET-381/FoxF directly activates the CC specification factor, the Six2 homeodomain protein CEH-34, and functions cooperatively with CEH-34/Six2 to directly activate genes required for CC differentiation. Our results unify a diverse set of studies on the functions of FoxF/FoxC factors and provide a model for how FoxF/FoxC factors function during mesoderm development.
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