期刊
DEVELOPMENT
卷 135, 期 3, 页码 411-424出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.000505
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资金
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- Medical Research Council [G0300723B] Funding Source: researchfish
The Wnt and Notch signalling pathways represent two major channels of communication used by animal cells to control their identities and behaviour during development. A number of reports indicate that their activities are closely intertwined during embryonic development. Here, we review the evidence for this relationship and suggest that Wnt and Notch ('Wntch') signalling act as components of an integrated device that, rather than defining the fate of a cell, determines the probability that a cell will adopt that fate.
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